A Sister's Fear: Down Syndrome, Alzheimer's Risk, and an Uncertain Future

Gina El Hassan, now 70, has growing concerns about her brother’s future. Rudolph Vincent Perez, her 56-year-old sibling, has Down syndrome and shows early signs of cognitive decline. She fears how she will care for him if his condition worsens. People with Down syndrome face a far higher risk of Alzheimer’s disease than the general population. The Alzheimer’s Association estimates their lifetime risk may reach up to 90%. Brain changes linked to dementia can also appear earlier, sometimes as young as 40.

Rudolph Vincent Perez has always loved music and dancing. But Gina El Hassan noticed changes years ago. He began forgetting where things belonged and lost interest in activities he once enjoyed.

Improved healthcare has helped people with Down syndrome live longer. Because of this, the Alzheimer’s Association is now prioritising research into dementia risks for those with intellectual and developmental disabilities. Gina El Hassan’s worries reflect a broader challenge for families. Longer lifespans mean more people with Down syndrome may face Alzheimer’s disease. Research and support systems will be critical in addressing their care needs.